Professional Freeze Dryer Machines | CoolVacuum - Advanced Lyophilization Solutions

Innovation in Lyophilization Since 2008

CoolVacuum, operating under the Dara-Lyo brand and integrated within the Dara Pharma Group, was established in 2008 to meet the growing demand for high-quality, GMP-compliant freeze dryers and loading systems in Spain and beyond.

Today, we are one of the few global manufacturers capable of delivering complete turn-key solutions for lyophilized injectable drugs — from concept and design to commissioning and validation.

8+ Sectors Served

Pharma, biotech, nutrition, cosmetics, R&D, and more.

Global Reach

Agents and clients across 50+ countries.

Premium Freeze Drying Equipment

From laboratory-scale units to full GMP production lines, CoolVacuum offers a comprehensive range of freeze dryers engineered for performance, scalability, and compliance.

LyoLab MINI

Compact laboratory freeze dryer ideal for R&D and small-scale lyophilization.

✓ Benchtop design
✓ GMP-ready options
✓ Integrated software control

LyoPharm

GMP-compliant freeze dryer for pharmaceutical production.

✓ Full validation support
✓ cRABs & isolator integration
✓ Scalable chamber design

LyoCompact

Space-efficient freeze dryer for pilot and small production batches.

✓ Low footprint
✓ High thermal efficiency
✓ Remote monitoring

BioFreezer

Advanced freeze-thaw system for biopharmaceutical processing.

✓ Precise temperature control
✓ Fast cooling rates
✓ Seamless integration

LyoNano

Ultra-compact freeze dryer for nanomaterials and sensitive compounds.

✓ Nanoscale precision
✓ Low energy consumption
✓ Touchscreen interface

LyoLab

Full-featured laboratory freeze dryer for advanced research.

✓ Multiple shelf options
✓ Data logging & export
✓ Customizable protocols

LyoEpic

High-capacity pilot freeze dryer for scale-up studies.

✓ Large chamber volume
✓ Automated cycle control
✓ PAT-ready sensors

LyoBiotic

Specialized freeze dryer for probiotics and nutritional products.

✓ Gentle drying process
✓ High viability retention
✓ Food-grade materials

View Full Product Catalog

Why Choose CoolVacuum?

Engineered excellence, global support, and innovation at every stage.

GMP & Regulatory Compliance

All equipment designed and validated to meet FDA, EMA, and WHO standards. Full documentation and qualification support included.

Turn-Key Integration

Seamless integration with filling lines, loading systems, and containment solutions. We deliver complete processing lines.

24/7 Global Support

Technical support, spare parts, maintenance plans, and remote diagnostics available worldwide — anytime you need it.

Comprehensive Global Services

From concept to qualification, we support your freeze drying journey every step of the way.

LyoTech Center

Innovation hub for R&D, process development, and feasibility testing using real equipment.

Qualification & Validation

IQ/OQ/PQ protocols, risk assessments, and full documentation packages.

Technical Audit & Optimization

Performance reviews, cycle optimization, and energy efficiency upgrades.

Training & Commissioning

On-site or remote training, startup, and commissioning support.

Aftermarket Support

Spare parts, predictive maintenance, and system upgrades available globally.

Project Management

End-to-end project coordination, from design to delivery and integration.

Frequently Asked Questions

What industries do CoolVacuum freeze dryers serve?

Our equipment is used in pharmaceutical, biotech, nutritional, cosmetic, chemical, and academic R&D sectors.

Are your freeze dryers GMP-compliant?

Yes, all GMP models are designed and validated to meet international regulatory standards including FDA 21 CFR Part 11 and EU GMP Annex 11.

Do you offer turn-key production lines?

Yes, we provide complete turn-key solutions including freeze dryers, loading systems, containment, and software integration.

Is technical support available internationally?

Yes, we offer 24/7 technical support, remote diagnostics, and on-site service through our global network of agents.

Can I test my product before purchasing?

Absolutely. Our LyoTech Center offers feasibility studies, cycle development, and pilot-scale testing with your materials.

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Advanced Freeze Dryer Technology for Global Industries