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Premium Nicotine Solutions for Global Brands

As a leading manufacturer of ultra-pure natural and synthetic nicotine, we power the world’s top e-cigarette, nicotine pouch, and next-generation delivery brands with unmatched purity, consistency, and supply security.

ZY Biotech High-Purity Nicotine

Trusted by ELFBAR, HQD, LOST MARY, WAKA & more

About NicoBest & ZY BIOTECH

A trusted name in high-purity nicotine manufacturing, backed by decades of pharmaceutical expertise and innovation.

ZY BIOTECH – A Legacy of Excellence

ZY BIOTECH is a wholly-owned subsidiary of QR Pharmaceuticals, founded in 2001. With over 20 years of experience in pharmaceutical R&D and production, we bring biopharmaceutical-grade standards to nicotine manufacturing.

Our group operates two pharmaceutical R&D centers, an API business unit, a biological platform, and a dedicated marketing center — ensuring innovation, quality, and scalability across all operations.

As the #1 nicotine supplier for the e-cigarette industry, we serve leading global brands with natural and synthetic nicotine that exceeds EP/USP monographs in purity and consistency.

ZY Biotech Manufacturing Facility

Our Premium Nicotine Products

Engineered for performance, purity, and consistency — trusted by the world’s leading nicotine delivery brands.

Natural Nicotine

  • 100% Natural Nicotine
  • ZERO GTI impurities
  • Ultra-pure, clean, stable
  • Outstanding organoleptic properties
  • Unrivaled batch-to-batch consistency
Ideal for e-cigarettes & vaping

Synthetic Nicotine

  • 100% Synthetic Nicotine
  • Pure (S)-Nicotine (99.7–99.9%)
  • Non-enzymatic chemical process
  • PCT license available
  • >30 tons/month batch capacity
High satisfaction at low concentration

Nicotine Salt (Liquid)

  • Liquid form for direct use
  • Smooth throat hit
  • Fast absorption
  • Ideal for pod systems
  • Customizable salt types
Optimized for e-liquids

Nicotine Salt (Solid)

  • Powder form for stability
  • Easy to transport & store
  • Precise dosing control
  • Ideal for nicotine pouches
  • Customizable particle size
Perfect for dry formulations

Nicotine Pouch Solutions

  • Powder solutions for pouches
  • Fast-release or slow-release
  • Flavor-neutral base
  • Consistent nicotine delivery
  • Compliant with regional standards
Ready for oral nicotine products

API-Grade Nicotine

  • Pharmaceutical-grade purity
  • Suitable for medical applications
  • Compliant with EP/USP standards
  • Full documentation & traceability
  • Ideal for patches, gums, lozenges
For regulated health products

Custom Nicotine Complexes

  • Tailored for specific delivery
  • Enhanced bioavailability
  • Controlled release profiles
  • Compatible with multiple matrices
  • R&D collaboration available
Innovative delivery solutions

Bulk Supply & Logistics

  • >60 tons/month capacity
  • Secure global supply chain
  • Export license & compliance
  • Dangerous chemicals certified
  • Just-in-time delivery options
Reliable, scalable supply

Why Choose NicoBest?

We combine pharmaceutical rigor with industrial scale to deliver the purest, most consistent nicotine on the market.

Unmatched Purity

Our natural nicotine has near-zero impurities, significantly exceeding EP/USP monographs. ZERO GTI impurities ensure safety and consistency.

Pharmaceutical-Grade Process

We apply biopharmaceutical production standards, including CNAS-certified laboratories and strict batch testing for every product.

Certified & Compliant

Full licensing: E-cigarette, dangerous chemicals production, and export. PCT patents available for synthetic nicotine.

Mass Production Capacity

Over 60 tons/month production capacity ensures reliable supply. Synthetic nicotine: >30 tons/month.

Trusted by Global Brands

Supplier to ELFBAR, HQD, LOST MARY, WAKA, and other top-tier brands in the vaping and nicotine pouch industries.

Dedicated Support

Professional service team ready to assist with technical, regulatory, and supply chain needs.

60+
Tons/Month Capacity
99.9%
Nicotine Purity
3
CNAS Labs
20+
Years Experience

Frequently Asked Questions

Everything you need to know about our nicotine products and services.

What is the difference between natural and synthetic nicotine?

Natural nicotine is extracted from tobacco plants and retains the natural (S)-nicotine isomer. Synthetic nicotine is chemically produced without using tobacco, offering identical molecular structure but with greater batch consistency and no plant-based impurities.

Do you offer custom formulations?

Yes, we provide custom nicotine salts, concentrations, and delivery formats (liquid, powder) tailored to your product needs. Our R&D team collaborates closely with clients.

Are your products compliant with international regulations?

Yes. We hold e-cigarette, dangerous chemicals production, and export licenses. Our products meet or exceed EP/USP standards and are suitable for global markets.

What is your minimum order quantity (MOQ)?

MOQ varies by product type and form. Please contact our team for specific details based on your requirements.

Can I get samples before placing an order?

Yes, sample requests are welcome. Contact us to discuss your needs and receive product samples for evaluation.

Get in Touch

Ready to elevate your nicotine product with the purest, most consistent supply?

Contact Information

Doris Chen
17278279283
Hubei Huangzhou Railway Station Economic Development Zone

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